Demenidazole, nk'igisekuru cya mbere cy'imiti y’udukoko twangiza udukoko, igiciro cyayo gito ituma ikoreshwa cyane mu gusuzuma no kuvura indwara z’amatungo.Nyamara, hamwe nogukoresha cyane ubu bwoko bwibiyobyabwenge hamwe nibisanzwe bisubira inyuma ndetse nigisekuru cya mbere cya nitroimidazoles, ikibazo cyo kurwanya ibiyobyabwenge mugukoresha byanze bikunze kizagaragara cyane.

01Ingaruka zo kurwanya anaerobic

Nyamara, gukoreshwa kwinshi mu musaruro w’inkoko bigaragarira cyane cyane muri bagiteri zirwanya anaerobic.Mu myaka icumi ishize, yakoreshejwe cyane mu kuvura inkoko ya nerotic enteritis, syndrome ya enterotoxic na oviduct inflammation.Nyamara, ibyiyumvo byayo kuri anaerobes bigenda byiyongera.Impamvu ni: kuva kera, gukoresha nabi no kuyikoresha bidakwiye byatumye kwiyongera kwa bagiteri zitandukanye za anaerobic kuri buri mwaka, kandi gukurikirana biracyakomeza.Mu rwego rwo gukumira iyi nzira mbi y’iterambere, ishami rishinzwe ubuvuzi bw’amatungo ryabujije mu buryo bweruye mu myaka irenga icumi ishize: rishobora gukoreshwa gusa mu bworozi no mu musaruro w’inyamaswa zikoreshwa cyane, kandi zishobora gukoreshwa gusa muri ubworozi bw'amatungo n'inkoko, amatungo hamwe n'ubworozi budasanzwe.

02Guhuza ubumenyi kandi bushyize mu gaciro

Mu rwego rwo guhuza imikoreshereze idahwitse ya demenidazole, mbere ya byose, ntigomba gukoreshwa hamwe na methamphenicol, florfenicol nizindi antibiyotike ya amido alcool, kuko demenidazole ishobora gutera amagufwa ya dysplasia mumatungo n’inkoko, kandi iyo akoreshejwe hamwe hamwe hejuru. amido alcoot antibiotique, bizongera ibyago byo kwitwara nabi mumaraso.

Icya kabiri, ntigomba gukoreshwa na Ethanol cyangwa imyiteguro irimo Ethanol nyinshi, kuko guhuza byombi bizatera disulfiram reaction, kandi inyamaswa zirwaye zishobora kugira ibimenyetso bimwe na bimwe byindwara zifata ubwonko.Byongeye kandi, gukoresha inzoga cyangwa ibiyobyabwenge birimo inzoga nyinshi bigomba kugabanuka bishoboka mu minsi 7-10 nyuma yo kunywa ibiyobyabwenge.

Icya gatatu, cyane cyane mubikorwa byubuvuzi bwamatungo, icya mbere, ntigomba guhuzwa nimiti ikingira indwara, bitabaye ibyo, demenidazole irashobora kubuza ingaruka za mycophenolate mofetil kumubiri.Icya kabiri, ntishobora gukoreshwa hamwe na anticoagulants yo mu kanwa, izamura ingaruka zo kurwanya anticagulant zo mu kanwa nka warfarin, ku buryo inyamanswa zifite ibyago byinshi byo kuva amaraso.

Hanyuma, ibi biri mubikorwa byubuvuzi bwamatungo.Ubwa mbere, ntishobora guhuzwa nibiyobyabwenge byumwijima enzyme inhibitor.Kurugero, imiti yumwijima enzyme inhibitor nka cimetidine irashobora kubuza metabolism ya metronidazole.Iyo bihujwe, ni ngombwa kumenya ibiyobyabwenge byamaraso hanyuma ugahindura igipimo ako kanya.Iya kabiri ni uko idashobora gukoreshwa hamwe na hepatike yimiti ya hepatike.Iyo uhujwe na hepatike yimiti ya hepatike nka phenytoin, metabolisme ya demenidazole izihuta kandi plasma igabanuke;Metabolism ya fenytoin hamwe nindi miti ya hepatike yimiti ya hepatike yadindije umuvuduko wa plasma wariyongereye.

03Imyiteguro igira ingaruka zo gukiza

Kubera ko demenidazole ubwayo ishobora gushonga gato mumazi kandi ni antibiotique iterwa nigihe, inenge yibiyobyabwenge nibiranga farumasi byerekana ko "imyiteguro igena imikorere".Dukunze kubona mubice byatsi-imizi ko gukemura ibicuruzwa bya dimenidazole premix ari bibi cyane.Nyuma yo kongeramo amazi menshi no kuvanga byuzuye, hariho "umubare munini wibintu bitangirika" murugero rwiza rwumucanga.Ntabwo mubyukuri "sofiya" yuwabikoze kugirango yite ikibazo cyamazi meza, cyangwa abeshya ko ibintu bitangirika ari ibintu byangiza nibindi biyobyabwenge.

Ibicuruzwa byose byateganijwe mbere ya dimenidazole, usibye guhendutse kandi bihendutse, byahujwe "nta ngaruka".

Kubwibyo, benshi mubahinzi-borozi-nyakatsi n’abakoresha ibiyobyabwenge byamatungo bagomba kwitondera ibicuruzwa "byujuje ubuziranenge" bifite ibiyobyabwenge bihagije kandi bikemuka neza mugihe bahisemo ibicuruzwa bya dimenidazole primaque yo kuvura indwara za anaerobic mumyanya yumubiri cyangwa sisitemu yimyororokere.Usibye gutoranya ibiyobyabwenge, intambwe yingenzi ni: dukurikije ukuri kugaragara ko kongera ibiyobyabwenge, tugomba gukora akazi keza muguhuza, guhuza no gukoresha imiti igabanya ubukana, kugirango tuzamure kandi tugaragaze “Imikorere” yo kuvura ibiyobyabwenge.